Xu Tang was enraged. Nothing was more humiliating than being reprimanded by one's love rival, especially when it was something that only concerned him. Who the hell do you think you are? I'm only speaking because I think your little sister is too pitiful.
What riled up Mu Zhichen the most was that Lu Meili had to risk her life to that extent. No matter how one looked at it, Lu Meili couldn't be blamed for being rash.
Even if that car wouldn't fall off, it would have exploded before Small Xixi got rescued. In fact, she should be praised from being brave. However, none of this could change the fact that she was his beloved. It would still be slightly fine if it was someone else. But just what right did the Xu family have to get her to love them so much? She valued them more than her life but did they ever appreciate it?
It made the whole situation sound like she owed the Xu family in her previous lifetime and was currently repaying it in this lifetime. Xu Tang narrowed his eyes coldly at Mu Zhichen. Everyone saw it Mu Zhichen was the one picking a fight with him. He shouldn't be blamed if he retaliated.
He didn't know that it was deliberately meant for him to keep losing his temper in Lu Meili's presence. I wouldn't be if I were you. You understand -- just like everyone else does that Lu Meili doesn't love you.
You are just an option she picked up because she was heartbroken. A substitute. That's what you are. Mu Zhichen's hands itched for violence. This man was quite something. How could one person afford to be so idiotic?
Are you sure he had not gathered up everyone's lifetime supply of idiocity and pumped it into his brain?Joo Se Hyuk - The Ultimate Defender
Wait, did he even have a brain to begin with? Mu Zhichen forgot about that idiot. We can go home after your friend gets out of danger, okay? It was not everyday she risked her own life like that. That moment when she thought she and Small Xixi were going to die, right before Mu Zhichen appeared out of thin air and grabbed her hand, she was terrified. Holding two women up against gravity must have hurt. It was shocking that his bones were not dislocated. When Mu Zhichen saw the trace of worry in her eyes, he showed her his arm.
We also observe that pre-existing CTLs within the tumor are sufficient and essential for sumIL-2 therapy. In addition, preoperative sumIL-2 treatment extends survival much longer than standard adjuvant therapy. Finally, Ab-sumIL2 overcomes resistance to immune checkpoint blockade through concurrent immunotherapies.
Therefore, this next-generation IL-2 reduces toxicity while increasing TILs that potentiate combined cancer therapies. Interleukin-2 IL-2a T-cell growth factor induced by antigen stimulation, is a pleiotropic cytokine that plays pivotal roles in the immune response 12.
As a potent inducer of cytotoxic T cells and NK cells, IL-2 was one of the first FDA-approved immunotherapy drugs for metastatic melanoma and renal cell cancer 34. Unfortunately, IL-2 immunotherapy has not been widely applied due to its short half-life in vivo and severe toxicity at the therapeutic dosage 567.
Safety checking of machine code
Some strategies introduce specific mutations to IL-2 IL-2 muteins to induce preferential binding to either CD25 or CD, thus stimulating specific immune cell subsets. An IL-2 mutein with decreased affinity to CD25 mainly expressed on pulmonary endothelial cells and Treg cells was developed to possess more effective tumor therapeutic effects than the wild-type IL-2 13 However, the higher affinity of IL-2 over the antibody might actually limit tumor targeting of Ab-IL2.
Several recent studies show that immunocytokine efficacy and biodistribution of IL-2 variants may not be sufficiently attributed to tumor-antigen targeting 22 Systemic delivery of Ab-IL2 may likely activate T cells in lymphoid and nonlymphoid tissues that contribute to severe toxicity and limited antitumor efficacy.
The increase of tumor-infiltrating lymphocytes TILs is an important biomarker for predicting responses to PD-L1 blockade therapy The functions of IL-2 therapy are known to directly activate CTLs in lymphoid and nonlymphoid tissues 1725but it is not yet clear whether the preexisting T cells inside the tumor are sufficient for the effectiveness of IL-2 therapy.
While most recent studies have focused on checkpoint blockade 1426more attention should be paid to the increased Tregs inside the tumor microenvironment TME that limit IL-2 binding to and subsequent stimulation of CTLs. Despite high objective response rates, most patients exhibit tumor relapse several months after treatment To protect your privacy, all features that rely on external API calls from your browser are turned off by default.
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Meili, why don't the two of you walk around? Lu Aotian and Mr. Mu were already catching up, probably over a game. Had she decided to call off the engagement? Just who did she meet today? If it happened to be Xu Tang, nothing good could possibly come out of it. Don't you think it's too rushed?
One day I'm an unattached woman, the next day I'm going to be engaged and within three months, I'll be married as well? It doesn't make any sense to me.
Perhaps since my parents met because of a marriage agreement, got married in a flash and fell in love within a few days, they expect it to be the same for me. I don't want you to be uncomfortable about anything.
She still needed time to let her feelings build up. Wan Jia was chopping vegetables at a remarkable speed. The kids will solve their problems on their own. Just like her grandson, matriach Mu was walking on needles. What if Lu Meili had been offended by them and was going to cancel the engagement?
She had to admit, she was previously irked by Mu Zhichen's lack of interest in women. When she was finally informed that not only was he bringing a woman home, that woman was also a daughter of the Lu family, she had been overjoyed.
Wan Jia was not worried. She knew that if Lu Meili didn't want to marry, she would have said so before sending out the invitation cards. At the dining table, matriach Mu snuck glances at her grandson, trying to detect if he was heartbroken.
My Beautiful Love Book 2 Chapter 580
Although Lu Meili couldn't be considered a neat freak, she couldn't eat food from someone else's cutlery. She could only accept such actions from Lu Xian Yu.Thanks for helping us catch any problems with articles on DeepDyve.
We'll do our best to fix them. Check all that apply - Please note that only the first page is available if you have not selected a reading option after clicking "Read Article". Include any more information that will help us locate the issue and fix it faster for you. Our safety-checking technique operates directly on the untrusted machine-code program, requiring only that the initial inputs to the untrusted program be annotated with typestate information and linear constraints.
This approach opens up the possibility of being able to certify code produced by any compiler from any source language, which gives the code producers more freedom in choosing the language in which they write their programs.
It eliminates the dependence of safety on the correctness of the compiler because the final product of the compiler is checked.
It leads to the decoupling of the safety policy from the language in which the untrusted code is written, and consequently, makes it possible for safety checking to be performed with respect to an extensible set of safety properties that are specified on the host side. We have implemented a prototype safety checker for SPARC machine-language programs, and applied the safety checker to several examples.
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My Beautiful Love Book 2 Chapter 581
Let us know here. System error.A trust network is defined for The method according to one embodiment comprises calculating a first feature vector for a first user, calculating a second feature for a second user and comparing the first feature vector with the second feature vector to calculate a The method of the present invention comprises saving one or more content items and one or more associated A cache is Inventors: Zhichen Xu Yahoo!
Content items such as user-generated events are received from a variety of sources. One or more content items are added to a set of content items based on a diversity of characteristics The system collecting documents viewed or words posted by a user. Determining a list of topic words for the user based on words in the documents viewed or words posted.
Identifying a list of topic words associated with the The method according to one embodiment comprises selecting an item from the result set, selecting a user profile from one or more user profiles and selecting one or more items of personalized information from the selected An interest twin of a user in another user that has demonstrated interests in items that are the same as or similar to the items in which the user has demonstrated an interest.
Various techniques are described The documents are parallelized and distributed across a plurality of network devices, which place at least some of the received documents into Relevance ranking techniques in organizing distributed system indices. Query-centric configuration subprocesses 1 analyze query data, partitioning terms for reverse index server s RIS2 distribute each partitioned data set by generally localizing search terms for the RIS Inventors: George H.
Excalibur Ip, LlcYahoo! If Zhichen Xu filed recent patent applications under another name, spelling or location then those applications could be listed on an alternate page.
If no bibliographic references are listed here, it is possible there are no recent filings or there is a technical issue with the listing--in that case, we recommend doing a search on the USPTO.
Sign up for the FreshPatents. You will be notified when new patent applications and inventions are published that match your keywords. It takes only 30 seconds to sign up or login.Zhichen Xu has filed for patents to protect the following inventions. Search system and methods with integration of user annotations from a trust network. Publication number: Abstract: Computer systems and methods incorporate user annotations metadata regarding various pages or sites, including annotations by a querying user and by members of a trust network defined for the querying user into search and browsing of a corpus such as the World Wide Web.
Users can also limit searches to content annotated by members of their trust networks or by members of a community selected by the user.
Type: Application. Filed: November 13, Publication date: March 8, Patent number: Type: Grant. Filed: May 30, Date of Patent: December 26, Abstract: The present invention is directed towards systems and methods for trust propagation. The method according to one embodiment comprises calculating a first feature vector for a first user, calculating a second feature for a second user and comparing the first feature vector with the second feature vector to calculate a similarity value.
A determination is made as to whether the similarity value falls within a threshold. If the similarity value falls within the threshold, a relationship is recorded between the first user and the second user in a first user profile and a second user profile.
Filed: January 6, Publication date: April 27, Rose, Abe Taha, Farzin Maghoul. User interface for navigating a keyword space. Abstract: The present invention relates to systems, methods, and user interfaces for browsing a collection of content items saved by a user or by one or more buddies associated with a given user. The method of the present invention comprises saving one or more content items and one or more associated keywords as specified by a user.
An interface is generated that displays the one or more saved content items and the one or more associated keywords, as well as the one or more buddies associated with a given user.
A user indication of the selection of a given keyword or the selection of a given buddy by the user is received. The one or more displayed content items are filtered according to the selected keyword, buddy, or combination of selected keyword and buddy.
Filed: January 2, Date of Patent: February 21, Trust propagation through both explicit and implicit social networks. Filed: April 9, Asymmetric identification of interest twins in an online community.